Skip to main content
. 2012 Jun 21;8(6):e1002755. doi: 10.1371/journal.ppat.1002755

Figure 9. The Arg knob-in-hole interaction is critical for species selectivity and interaction with invasion inhibitory antibodies and peptides.

Figure 9

(A). Left - A cut-away surface of PfAMA1 (blue), reveals that Arg2041 of PfRON2sp1 (orange) integrates deeply into a well-defined pocket. Right - However, no analogous pocket is observed in PvAMA1 (grey; PDB ID 1W8K). (B). Peptides and antibodies known to be invasion inhibitory for P. falciparum occupy the key Arg binding site, as shown by orthogonal views of the PfAMA1-PfRON2sp1 co-structure (blue-orange) overlayed with the mAb 1F9 co-structure (1F9, green; PDB ID 2Q8B), IgNAR14l-1 co-structure (IgNAR, purple; PDB ID 2Z8V), and R1 co-structure (R1, yellow; reported here).