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. 2012 Feb 27;55(6):2894–2898. doi: 10.1021/jm201212h

Scheme 1. Synthetic Route to Compounds 7a–m.

Scheme 1

Reagents and conditions: (a) ethynyltrimethylsilane, Pd(PPh3)2Cl2, CuI, MeCN, diethylamine, microwave 120 °C, 15 min, then K2CO3, MeOH, rt, 2 h, 85%; (b) bromoaryl/heteroaryl, Pd(PPh3)2Cl2, CuI, MeCN, diethylamine, microwave 80–120 °C, 15 min, 22–63%; (c) KMnO4, phosphate buffer; (d) aldehyde, ammonium acetate, n-butanol, 50–65 °C, 0.5–5 h, 10–63%.