Table 1.

Serum analyte concentrations in patents given bisphosphonates

	Adjusted calcium (mmol/l)	Magnesium (mmol/l)	Parathyroid hormone (pmol/l)	Vitamin D2 (ng/ml)	Vitamin D3 (ng/ml)
Reference range	2.20-2.60	0.75-1.00	1.1-6.8	<10	>15
Case 1
Before starting bisphosphonate	2.36
6 days before starting (after chemotherapy)	2.09		21.9
3 days after	1.17	0.70	22.4
4 days after	1.11		35.4	<4.0	8.0
14 days after	2.36
Case 2
Before starting bisphosphonate	3.21	0.33	<0.7
5 days after	2.58		<0.7
7 days after	2.14		<0.7
9 days after	1.48	0.38	<0.7
11 days after	2.07	0.82	23.2
Case 3
Before starting bisphosphonate	2.96	0.89	<0.7
5 days after	1.79	0.67	14.1	<4.0	5.0
15 days after	2.22	1.03	12.6
Case 4
Before starting bisphosphonate	4.12		<0.7
5 days after	2.34	0.83	<0.7	<4.0	32.0
9 days after	1.66	0.92	<0.7
19 days after	2.28	1.02	<0.7