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Differential association mode of Gα12 protein with PAR1 and other GPCRs. (A) BRET and TR-FRET data demonstrated that PAR1 is preassembled with Gαi1, but not Gα12 which is only recruited after receptor activation (Ayoub et al., 2010). (B) In contrast to PAR1, Gα12 can be preassembled with other GPCRs such as 5-HT2c, V1aR, and M3R (Ayoub et al., 2010).
