FIGURE 1.

Requirement of integrin βν for host defense against septic infection with S. aureus. Adult flies of control (w¹¹¹⁸) (closed symbols) and integrin βν-deficient (betaInt-nu²) (open symbols) lines were infected with wild-type S. aureus (strain RN4220) by injury (injection at the abdomen) (left in A and B) or feeding (right in A), and subjected to an analysis of fly survival (A) and bacterial growth (B) at the indicated periods. The square symbols in the left panel of A denote the results for flies injected with solvent (PBS) alone. In A, data from one of three independent experiments that yielded similar results are presented. In B, cfu values at 24 h relative to those at 0 h were compared between w¹¹¹⁸ and betaInt-nu². Genotype of the fly line analyzed is w; betaInt-nu² (betaInt-nu²).