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. 2012 May 8;287(26):21686–21698. doi: 10.1074/jbc.M111.328054

FIGURE 5.

FIGURE 5.

Exhaustive correlation analyses between miR-449a/b- and miR-34b/c-induced mRNA transcriptomic changes in human airway mucociliary epithelial cells. A, significant down-regulation (p < 1.27e−09; two-tailed Wilcoxon rank sum test) of mRNAs (red line) possessing predicted binding motifs for the miR-449a/b seed region as compared with mRNAs lacking miR-449a/b binding motifs (black line). B, significant down-regulation (p < 6.720e−29; two-tailed Wilcoxon rank sum test) of mRNAs (red line) possessing predicted binding motifs for the miR-34b/c seed sequence compared with mRNAs lacking miR-34b/c binding motifs (black line). C, mRNA transcriptomic changes induced by miR-449a/b are highly correlated with those by miR-34b/c. -Fold changes are represented as log2 scale. Pearson's correlation coefficient r = 0.86.