FIGURE 6.

α-Catulin levels are reduced at the sarcolemma and neuromuscular junctions of α-dystrobrevin-deficient mouse muscle. A, α-catulin level is reduced in α-dystrobrevin-null (α-DB^−/−) hindlimb muscle extract. Left, representative immunoblot with anti-α-catulin antibody (clone 5G8). Right, quantification of relative intensity normalized to the level of GAPDH. Error bars, S.D. *, p < 0.05 (two-tailed Student's t test). B, α-catulin is reduced at the sarcolemma of α-DB^−/− muscle (tibialis anterior). Scale bar, 10 μm. C, α-catulin is reduced at the neuromuscular junctions of α-DB^−/− muscle (tibialis anterior). AChR, the neuromuscular junctions were identified by the presence of acetylcholine receptors (α-bungarotoxin).