Skip to main content
. 2012 May 8;287(26):21773–21782. doi: 10.1074/jbc.M112.363226

FIGURE 7.

FIGURE 7.

a, effects of (first treatment) saline (S), 2-PMPA (PM; 50 mg/kg, i.p.), or 2-PMPA with LY341495 (LY; 1 mg/kg, i.p.) and (second treatment) saline or PCP (5 mg/kg, i.p.) on DA levels in the mPFC. The S-PCP treatment produced a significant DA increase compared with the S-S treatment group (p < 0.001). PM-S had no effect on DA levels (p = 0.98 versus S-S). PM-PCP pretreatment did not reach significance versus S-PCP (p = 0.14), whereas PM + LY had no significant effect on PCP-induced DA release (p = 0.31). The S-S and S-PCP data presented here are the same as in Fig. 6a. *, p < 0.05; **, p < 0.01; ***, p < 0.001, S-S versus S-PCP. b, effects of (first treatment) saline (S), 2-PMPA (PM; 50 mg/kg, i.p.), or 2-PMPA with LY341495 (LY; 1 mg/kg, i.p.) and (second treatment) saline or PCP (5 mg/kg, i.p.) on DA levels in the NAc. S-PCP produced a significant DA increase compared with S-S group (p < 0.001). PM-S treatment had no effect on DA levels compared with S-S group (p = 0.41). Pretreatment with PM or PM + LY also had no detectable effect on PCP-induced DA release (p = 0.94 and p = 0.33, respectively). The S-S and S-PCP data presented here are the same as in Fig. 6b. **, p < 0.01; ***, p < 0.001, S-S versus S-PCP.