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. 2012 May 3;287(26):21957–21969. doi: 10.1074/jbc.M112.339796

FIGURE 1.

FIGURE 1.

The α7 nAChR ligand binding domain model and structures of partial agonists. A, 4OH-GTS-21 in the α7 nAChR ligand binding domain of a homology model. The key elements of the α7 receptor were modeled using the 2WN9 (PDB ID) template. Residues within 5 Å of the phenyl ring of 4OH-GTS-21 are displayed except Trp-55, which is located behind the ligand and is hidden to clarify this presentation. B, the structures of 4OHGTS-21 and the six arylidene anabaseines used in this study are displayed and annotated with their corresponding hydrogen bonding properties.