FIGURE 7.

Energy landscapes for ACh, FAB, and PyroAB agonists with different α7 receptors at high ligand occupancy level. Under equilibrium conditions, the distribution of receptors into the resting closed (C), open (O), PNU-120596-sensitive desensitized (D_s), and PNU-120596-insensitive desensitized (D_i) states are determined by the relative free energy of the states (represented by vertical displacements). The graphs were constructed as described in the text. The experimental support for transitions shown in bold are discussed in the text.