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Effects of GMX1778 and niacin in a p53-inducible Tet-Off system. A, in the H1299-Tet-Off system, expression of wild-type p53 is allowed when tetracycline (Tet) is removed from media for 24 h. B, measurement of DHE oxidation with various concentrations of GMX1778 in the absence or presence of 20 μm niacin after 48 h of treatment. −p53 cells media contained 1 μg/ml of tetracycline. (*, significantly different from control, p < 0.05; **, p < 0.005.)
