Fig. 3.
Capsazepineprevented the inhibition of Ih by capsaicin. (A) Representative current responses of DRG neurons to 1-s voltage pulses injected in 10-mV increment under control condition, during application of 1 µM capsaicin (CAP), during application of 10 µM capsazepine (CZP) and subsequent addition of CAP. (B) Current-voltage relationship of Ih. Amplitudes of Ih in the presence of CAP, CZP and CAP+CZP were compared with those of control Ih at the same test voltage. (C) Normalized tail current was plotted versus various potentials (-60 to -130 mV) and fitted with Boltzmann equation. Estimated V1/2 was not significantly changed by CAP+CZP.