Table 1.
Intrinsic properties of dentate gyrus granule neurons are unaffected by Ophn-1 expression
| Ophn-1+/y | Ophn-1-/y | P | |
|---|---|---|---|
| Resting Membrane Potential (mV) | −73.8 ± 2.4 | −72.9 ± 1.9 | 0.81 |
| Input resistance (MΩ) | 351.3 ± 39.8 | 382.8 ± 62.2 | 0.75 |
| Membrane capacitance (pF) | 93.3 ± 10.1 | 78.2 ± 6.6 | 0.27 |
| Firing frequency (Hz) | 56.3 ± 7 | 67.3 ± 9.5 | 0.39 |
| Action potential threshold (mV) | −37.3 ± 3.5 | −41.4 ± 1.4 | 0.36 |
| Action potential half-width (ms) | 1.55 ± 0.09 | 1.61 ± 0.08 | 0.68 |
| Fast AHP (mV) | −4.1 ± 1.8 | −3.4 ± 1.5 | 0.81 |
| Slow AHP (mV) | −3.7 ± 0.8 | −2.4 ± 0.6 | 0.23 |
Resting membrane potential was the average potential recorded over 200 ms prior to a 200 ms, 300 pA current injection. Membrane resistance was calculated using a 100 pA hyperpolarising current injection. Membrane capacitance was calculated from the input resistance and the time constant, as Cm=τm/Rin.