Table 5.

Changes in the relative efficacy of the M channel enhancers to augment M current during PIP₂ depletion or Ca²⁺/CaM saturation

		Enhancer (Ibasal/Ienhancer)/(Iinhib/Iinhib+enhancer)
Vm	Inhibitory conditions	Flu	Rtg	ZnPth	H2O2
−60 mV	Ptase/Rapa	1.02†	2.05*	1.24†	1.1†
−60 mV	Ca2+/CaM	0.9†	0.57‡	1.34*	—
0 mV	Ptase/Rapa	1.1†	1.36*	1.69*	1.9*
0 mV	Ca2+/CaM	1.34*	1.23†	1.64*	—

Ratios of I_basal/I_enhancer divided by I_inhib/I_{inhib+enhancer} were calculated from the M current amplitudes measured at 0 and –60 mV in basal conditions (I_basal), during PIP₂ depletion or Ca²⁺/CaM saturation (I_inhib) or during PIP₂ depletion or Ca²⁺/CaM saturation after the application of enhancer (I_{inhib+enhancer}). ^*R > 1.25; †R = 0.75−1.25; ‡R < 0.75. A ratio of 1 indicates that the fractional increase in current induced by the enhancer is the same under basal or inhibited conditions.