Table 3.
Aβ–binding DNA decamers predicted by dynamic weight search
| Gene | Locationa | Orien. | Sequenceb | Gene | Location | Orien. | Sequence |
|---|---|---|---|---|---|---|---|
| APOE | −3001 | F | TAGGTTGGGG | BACE1 | −193 | R | GTCTGCCCTC |
| APOE | −2288 | R | GGGGTAGGAG | BACE1 | −118 | R | TCTCCCGTAG |
| APOE | −2235 | R | GGGGTAGGGG | BACE1 | 335 | R | GACCGCAGGA |
| APOE | −847 | F | TGGGGAGGGG | BACE1 | 823 | R | CCTGTCGTCC |
| APOE | −325 | R | GGGGAGAGGT | BACE1 | 881 | R | TTCACAAGGG |
| APOEc | 170 | F | GGGCTTGGGG | BACE2 | −591 | F | GGGGGTGGGG |
| APOE | 265 | F | TGGGGTGGGG | IDE | −1229 | R | GGGGTCGGGT |
| APOE | 547 | F | TGGGGAGGGG | MAPT | −2352 | R | GGGGAAGGGT |
| APOE | 553 | F | GGGGGTGGGG | MAPT | −2069 | F | GGGGTTGGGG |
| APOE | 618 | F | GGGGATGGGG | MAPT | 614 | F | GGGGGAGGGG |
| APOE | 664 | F | TGGGTTGGGG | MAPT | 964 | F | TGGGGAGGGG |
| APPd | −3831 | R | GGGGTGGGGG | OLIG2 | −1969 | R | GGGGTGGGGG |
| APP | −2873 | F | TAGGATGGGG | SLC38A1 | 93 | R | GGGGTGGGGG |
| APP | 745 | R | GGGGTAGGGG | TP53 | −2 | F | GGGATTGGGG |
| ASCL1 | −3871 | R | GGGGTGGGAG | TP53 | 258 | F | GGGGGTGGGG |
| ASCL1 | −958 | F | TGGGGAGGGG | ||||
| ASCL1 | −504 | R | GGGGTGAGGG | ||||
| ASCL1 | −339 | R | GGGGTGGGGG | ||||
| ASCL1 | −116 | F | GGGAGTGGGG | ||||
| ASCL1 | −81 | F | GGGAGTGGGG | ||||
a
Location is the 5’–most base of the decamer, relative to the +1 TSS.
b
Sequence of reverse–orientation decamers is reverse–complemented.
c
Boldface indicates confirmation of this sequence by EMSA.
d
This decamer crosses a previously characterized APP single–nucleotide polymorphism (underlined)