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. 2012 Jul;19(7):300–306. doi: 10.1101/lm.024901.111

Figure 1.

Figure 1.

Multiple retrieval events can alter the requirement for protein synthesis in reconsolidation. (A) Procedure for the five conditions that varied the number and timing of retrievals. In all conditions, one group received anisomcyin (ANI) and another received ACSF as a control. (B) ANI produces long-term impairments when given immediately following a single retrieval (ACSF = 15, ANI = 14), or a second retrieval that is spaced 24 h (ACSF = 17, ANI = 16) or 1 wk (ACSF = 9, ANI = 9) apart from the first retrieval event. However, no long-term deficits are noticed when the same drug is given immediately following a second retrieval that was spaced only 1 h (ACSF = 15, ANI = 15) or 6 h (ACSF = 10, ANI = 11) after the first retrieval event. Outset shows the deficit observed in animals receiving ANI following retrieval relative to animals receiving ACSF. As the timing of the second retrieval relative to first increases, the ANI-induced memory impairment increases. (*) P < 0.05 from ACSF control.