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Model showing how conditions associated with pulmonary hypertension development promote HIF-1α regulation of pulmonary arterial smooth proliferative remodeling that appears to be controlled by a Cyclin B1/CDK1-mediated phosphorylation of DRP1, which causes mitochondrial fission needed for their even distribution of during mitosis. The model also highlights approaches described in the text which were used to elucidate mechanisms.
