Panel A - Myriocin (6 μM) significantly protected LNCaP cells from γTE- induced death as indicated by MTT assays. *P<0.05, the difference between cells with myriocin (+M, solid bar) and without myriocin (open bar). Panel B and C - Effects of dihydrosphingosine and dihydroceramide on the viability of LNCaP and PC-3 cells. Cells were treated with dihydrosphingosine (dhysph, 25 μM) and dihydroceramide (dhycer, 25 μM) for indicated times and cell viability was analyzed by the MTT assays. **P<0.01 and *P<0.05, the difference between sphingolipid treatment and controls.