Table 1. MICs for 54 Burkholderia pseudomallei isolates, Phnom Penh, Cambodia, July 1, 2007–January 31, 2010*.
| Antimicrobial drug | MIC, µg/mL |
MIC50 | MIC90 | Breakpoints, µg/mL |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.38 | 0.5 | 0.75 | 1 | 1.5 | 2 | 3 | 4 | 6 | 8 | S | R | ||||||
| Meropenem | 3 | 29 | 16 | 1 | 3 | 2 | – | – | – | – | 0.5 | 1.5 | <4 | >16 | |||
| Doxycycline† | – | 13 | 19 | 18 | 3 | 1 | – | – | – | – | 0.75 | 1 | <4 | >16 | |||
| Ceftazidime† | – | 2 | 0 | 18 | 25 | 7 | 2 | – | – | – | 1.5 | 2 | <8 | >32 | |||
| Amoxicillin/ clavulanic acid | – | 1 | 0 | 13 | 30 | 7 | 2 | 1 | – | – | 1.5 | 2 | <8 | >32 | |||
| Chloramphenicol | – |
– |
– |
– |
1 |
1 |
0 |
17 |
16 |
12 |
|
|
|
6 | 8 | <8 | >32 |
| 0.032 |
0.038 |
0.047 |
0.064 |
0.094 |
0.125 |
0.19 |
0.25 |
0.38 |
0.75 |
1 |
1.5 |
3 |
|||||
| Sulfamethoxazole/ trimethoprim | 3 | 1 | 7 | 12 | 5 | 9 | 4 | 7 | 1 | 1 | 3 | 1 | 0 | 0.125 | 0.75 | <2 | >4 |
*MICs determined by Etest (AB Biodisk, Solna, Sweden). MIC50, MIC for 50% of isolates; MIC90, MIC for 90% of isolates; S, susceptible; R, resistant; –, no isolates with this MIC. †53 isolates included.