Table 1.

Role of Different Molecules in Macrophage Recruitment to AT.

Molecule	Model	Change in ATM	Insulin Sensitivity	Reference
Chemokines
MCP-1	Knockout	↓	Improved	[8]
MCP-1	Knockout	↔	No change	[11, 12]
MCP-1	AT overexpression	↑	Worsened	[7, 8]
CXCL14	Knockout	↓	Improved (females only)	[15]
CCL5	Elevated in visceral AT in humans		Correlated with inflammatory cytokines in AT	[18]
Chemokine Receptors
CCR2	Knockout	↓	Improved	[9, 10]
CCR2	Pharmacologic antagonist	↓	Improved	[9, 13, 14]
CCR2	Bone marrow transplant of CCR2−/− into ob/ob mice	↓	Improved	[14]
CXCR2	Bone marrow transplant of CXCR2−/− into wild type mice	↓	Improved	[17]
Inflammatory Mediators
Complement Factor 3a	Receptor knockout	↓	Improved	[19]
TLR4	Deficiency	↓	Improved	[22]
TLR4	Mutation (C3H/HeJ)	↔ but less inflammatory	Improved	[23, 24]
TLR4	Mutation (10ScN) on diet rich in saturated fatty acids	↔ but less inflammatory	Improved	[25]
TLR4	Bone marrow transplantation of TLR4−/− in C57BL/6 with high fat diet feeding	↓	Improved	[26]
TLR4	Bone marrow transplantation of TLR4−/− in LDLR−/− with low fat diet feeding	↓	Unchanged	[27]