. Author manuscript; available in PMC: 2013 Apr 1.

Published in final edited form as: Eur J Inorg Chem. 2012 Apr;2012(12):1916–1923. doi: 10.1002/ejic.201101364

Table 1.

Per Gd relaxivities and DD(E) affinities for fibrin-targeted contrast agents shown in Figure 6. Per molecule relaxivities are four times higher. Relaxivities determined in Tris buffer or bound to human fibrin at 37 °C, 1.5 T. Inhibition constants, K_i, to soluble fibrin fragment DD(E). NR=not reported.

Compound	r₁ Tris Buffer	r₁ fibrin	% Increase	K_i DD(E) (μM)
Pep^N-Gd4-^NPep	18.2	23.1	27	1.1
Gd4-^NPep	15.5	20.7	33	4.7
^NPep-Gd4	NR	NR	NR	9.1
Gd2A-^NPep-Gd2A	NR	NR	NR	12.0
Gd2B-^NPep-Gd2B	13.0	18.0	37	4.7
Gd2-Gly2-^NPep-Gd2	12.4	17.8	37	4.0
Gd2-T-^NPep-Gd2	13.3	28.0	114	3.5