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(A) Magnetic coupling between T1 and T2 contrast materials and the possible structures of various T1/T2 bimodal MRI contrast agent. (B) T1 and T2 MR imaging of MnFe2O4-Gd MNS with a variable thickness of SiO2 shell. With increasing SiO2 layer R1 increases and R2 decreases. (C) Synthesis of gadolinium-labeled MNS as a dual contrast agent for T1 and T2 weighted magnetic resonance imaging [148].
