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. Author manuscript; available in PMC: 2013 May 15.
Published in final edited form as: Clin Cancer Res. 2012 Mar 31;18(10):2905–2912. doi: 10.1158/1078-0432.CCR-11-2994

Table 2.

Median survival in months (95% CI) for patients with different stages of disease by metformin use

All Patients
(n=302)
Metformin
(n=117)
Nonmetformin
(n=185)
P value
All patients 12.8 (11.0–14.7) 15.2 (12.6–17.8) 11.1 (8.9–13.3) 0.009
Stage
   Resectable 28.2 (19.7–36.8) 31.0 (15.2–46.8) 21.4 (14.4–28.3) 0.293
   Unresectable 13.8 (11.2–16.5) 15.5 (13.4–17.7) 11.0 (8.7–13.3) 0.001
   Metastatic   8.3 (6.9–9.7)   8.8 (7.0–10.6)   7.3 (5.5–9.1) 0.482
   Nonmetastatic* 16.6 (14.3–18.9) 20.8 (15.7–26.0) 14.8 (12.5–17.2) 0.005
*

Combined group of patients with resectable and unresectable disease.