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. Author manuscript; available in PMC: 2012 Jun 25.
Published in final edited form as: Structure. 2010 Oct 13;18(10):1364–1377. doi: 10.1016/j.str.2010.06.018

Figure 4. Intermolecular Recognition of individual nucleotides in CUGBP1 RRM1/2-RNA and RRM1-RNA Complexes.

Figure 4

(A–D) Intermolecular hydrogen bonds associated with recognition of U3-G4-U5-U6 by RRM2 in the RRM1/2-RNA complex (GUUGUUUUGUUU RNA sequence 1). The Watson-Crick edges of U3 (panel A), U5 (panel C) and U6 (panel D) are involved in three direct and two water-mediated hydrogen bonds. The Watson-Crick and Hoogsteen edges of G4 (panel B) are involved in two direct and one water-mediated hydrogen bonds.

(E–H) Intermolecular hydrogen bonds associated with recognition of U8-G9-U10-U11 by RRM1 in the RRM1-RNA complex (UGUGUGUUGUGUG RNA sequence 4). The Watson-Crick edges of U8, U10 and U11 are involved in four direct hydrogen bonds. The Watson-Crick and Hoogsteen edges of G4 are involved in three direct hydrogen bonds.

(I) Intermolecular hydrogen bonds associated with recognition of G11 in the RRM1/2-RNA complex (UGUGUGUUGUGUG RNA sequence 3). The Watson-Crick edge of G11 is involved in three direct and one water-mediated hydrogen bonds.

See also Figure S3.