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. 2012 Feb 14;1(2):e11. doi: 10.1038/mtna.2012.1

Figure 1.

Figure 1

A range of voltage parameters results in delivery of DNA plasmid expressing GFP to guinea pig skin using the SEP device. Guinea pig skin was injected intradermally with 100 µg of DNA plasmid expressing GFP (pgWIZ-GFP) and either left untreated or immediately pulsed with the SEP device at a voltage setting of 200, 100, 50 or 10 V for one pulse. Skin biopsies were harvested 48 hours later and observed by fluorescent microscopy (a) for determination of GFP positive signal or bright light (b) for determination of local treatment site reaction. Bar is included for approximation of site reaction size. GFP, green fluorescent protein; SEP, surface electroporation.