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. 2012 Feb 14;1(2):e11. doi: 10.1038/mtna.2012.1

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Copyright © 2012 American Society of Gene & Cell Therapy

Molecular Therapy-Nucleic Acids is an open-access journal published by Nature Publishing Group. This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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A range of voltage parameters results in successful delivery of tagged siRNA to guinea pig skin using the SEP device. Guinea pig skin was injected intradermally with 100 µg of siRNA-tagged with Alexa 488 and either left untreated or immediately pulsed with the SEP device at a voltage setting of 200, 100, 50 or 10 V for three pulses. Skin biopsies were harvested 48 hours later and observed by fluorescent microscopy for determination of positive signal. Bar is included for approximation of biopsy size. SEP, surface electroporation; siRNA, small interfering RNA.