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EC50 values and Relative Coactivator Binding Affinity (RCA) Values for rac-DPN, R-DPN and S-DPN
| ERα | ERβ | ||||
|---|---|---|---|---|---|
| Ligand | EC50 (nM) | RCA (%) | EC50 (nM) | RCA (%) | β/α RCA |
| E2 | 0.56 ± 0.06 | [100] | 0.9 ± 0.06 | [100] | 1 |
| rac-DPN | 3.4 ± 0.4 | 16.6 ± 1.9 | 0.71 ± 0.02 | 126 ± 3.0 | 7.6 |
| R-DPN | 2.9 ± 0.3 | 19.3 ± 2.0 | 0.8 ± 0.03 | 112 ± 6.0 | 5.8 |
| S-DPN | 6.2 ± 0.9 | 9.0 ± 1.3 | 0.76 ± 0.01 | 119 ± 2.0 | 13.2 |
Values are reported as the mean ± SD or range of two or more independent determinations
