Table 2.
Cognitively impaired subjects.
| Subject | Clinical diagnosis | CERAD diagnosis | No. of PET scans included | Year of last PET | Year of diagnosis | Year of death | APOE |
|---|---|---|---|---|---|---|---|
| 1 | Probable AD | Probable AD | 8 | 2001 | 2002 | 2002 | 3/3 |
| 2 | Probable AD | Probable AD | 9 | 2002 | 2007 | 2008 | 3/4 |
| 3 | Possible AD | Probable AD | 8 | 2001 | 2004 | 2004 | 3/4 |
| 4 | Possible AD + vascular dementia | Probable AD | 8 | 2001 | 2002 | 2004 | 3/3 |
| 5 | Dementia1 | Probable AD | 8 | 2001 | 2004 | 2007 | 3/3 |
| 6 | Amnestic MCI | Possible AD2 | 9 | 2003 | 2007 | 2008 | 2/3 |
The last PET included in analysis was prior to the diagnosis of dementia.
1
This individual exhibited a pattern of cognitive decline consistent with AD, but had one episode of hallucinatory events.
2
By CERAD criteria, a subject with an age-related plaque score of B must have clinically diagnosed dementia to be considered probable AD. A clinical diagnosis of MCI, although included in our cognitively impaired subject group, is only considered possible AD using CERAD criteria.