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. 2012 Apr 24;1(4):e20. doi: 10.1038/mtna.2012.11

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Copyright © 2012 American Society of Gene & Cell Therapy

Molecular Therapy-Nucleic Acids is an open-access journal published by Nature Publishing Group. This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Gene silencing efficiency of the QD-PEG/siRNAs complex. Suppression of BACE1 protein expression evaluated by western blot analysis. The level of BACE1 expression was reduced to 49.0 ± 8% by the QD-PEG/siRNA complex, 94.3 ± 1% by nontarget siRNA, 89.9 ± 7% by siRNA only, and 99.4 ± 5% by QD-PEG only. The expression of BACE1 protein was significantly downregulated compared with control, siRNA only, and QD-PEG only (P < 0.001). After transfection the QD-PEG/siRNAs complex, the expression of APP proteins was reduced to 78.4 ± 6% by QD-PEG/siRNAs complex, 96.3 ± 4% by nontarget siRNA, 87.3 ± 1% by siRNA only, and 98.7 ± 6% by QD-PEG only. PEG, polyethylene glycol; QD, quantum dots; siRNA, small interfering RNA.