Table 3.
Areas of white matter atrophy in patients compared with controls
| Brain area | x | y | z | Peak Z-score |
|---|---|---|---|---|
| Upper brainstem | 2 | −20 | −8 | 7.6* |
| Cerebral peduncle (L) | −14 | −10 | −16 | 6.96* |
| Cerebellar tracts | 0 | −42 | −28 | 6.13* |
| Orbito-frontal region (R) | 12 | 58 | −18 | 3.43 |
| 8 | 40 | −24 | 3.21 | |
| 24 | 56 | −16 | 3.14 | |
| Superior frontal tracts (R) | 4 | −28 | 74 | 3.1 |
The table reports peak voxel location and Z-score, exceeding P < 0.001 (uncorrected). *Peaks at which P < 0.05 with a FWE correction for multiple comparison. Coordinates (x, y, z) are given according to standard anatomic space using the Montreal Neurological Institute template. L = left; R = right.