Figure 2.

Sarkosyl-insoluble tau was decreased in the brain of trehalose-treated mice compared with non-treated or sucrose-treated animals (A), while trehalose treatment had no effect on sarkosyl-insoluble tau in the spinal cord (B). In trehalose-treated mice, the number of nerve cells with AT100-positive inclusions was drastically reduced in layers I–III of the cerebral cortex (C–F) and in the pontine nucleus of the brainstem (G–J). NT = no treatment; Su = sucrose-treated; Tr = trehalose-treated. *P < 0.05, **P < 0.01 and ***P < 0.001.