FIG 6.
Mdivi-1 and Drp1 siRNA inhibit mast cell mitochondrial translocation, degranulation, and preformed TNF secretion. A, Mitochondrial morphology before or after stimulation with SP and pretreatment with mdivi-1. Cells were stained with LysoTracker (green) and MitoTracker (red). B, Percentage of translocated mitochondria in resting, stimulated, and mdivi-1-treated cells. C, TNF secretion. D, β-hex release. E, β-hex release after treatment with Drp1 siRNA before SP stimulation (n = 3; *P < .05). Bars equal to 5 µm.