Table 1.

The residues of PrP found in secondary structural elements are construct and environment dependent

PrPc construct	Helix A	Helix B	Helix C	B1	B2	Buffer pH
(29–231)	144–156	172–193	200–227	?137–140?	?160–163?	5.2
(23–231)	144–155	175–193	200–219	128–131	161–164	4.5
(90–231)	144–156	172–193	200–227	128–131	161–164	5.2
(121–231)	144–154	170–193	200–217	128–131	161–164	4.5