Table 1.
Effect of acetazolamide on respiratory variables (during stable NREM sleep on CPAP) and electrolytes
| Variable (n = 12) | Baseline | Acetazolamide |
|---|---|---|
| Respiratory variables | ||
| Minute ventilation (l min−1) | 7.2 ± 0.3 | 8.4 ± 0.4* |
| Tidal volume (l) | 0.55 ± 0.03 | 0.71 ± 0.06* |
| Respiratory rate (breaths min−1) | 14.4 ± 0.7 | 13.9 ± 0.7* |
| End-tidal CO2 (mmHg) | 40.2 ± 0.8 | 32.5 ± 1.0* |
| Plasma electrolytes | ||
| [HCO3−] (mmol l−1) | 23.8 ± 0.7 | 19.3 ± 0.6* |
| [Na+] (mmol l−1) | 139.5 | 138.5 |
| [137.5–140.0] | [137.3–141.0] | |
| [K+] (mmol l−1) | 4.3 ± 0.1 | 3.6 ± 0.1* |
| [Cl−] (mmol l−1) | 102.5 ± 0.7 | 108.6 ± 0.9* |
| BUN (mg dl−1) | 16.0 [15.0–19.5] | 20.0 [17.3–23.8]* |
| Creatinine (mg dl−1) | 0.98 ± 0.05 | 1.15 ± 0.05* |
| BUN/creatinine ratio | 17.6 ± 1.3 | 18.7 ± 1.4 |
Values are means ± SEM or medians [interquartile range].
*
Significant difference compared with the baseline condition. Electrolyte measurements during baseline and acetazolamide studies were obtained from a venous blood draw in the evening prior to the research night.