Figure 2.
Donor cells incorporate within many retinal layers of mnd mice and acquire retinal cell–like morphologies. Transplanted cells expressing enhanced green fluorescent protein are found integrated within the inner layers and outer plexiform layer of the host retina and are widely distributed by 16 weeks after transplantation (A). Retinal cell-like morphologies are seen in most layers, including donor cells that resemble ganglion cells (B–D), extensive branching within the inner plexiform layers (E–G), amacrine cell–like cells (H–J), bipolar cell–like cells (K–M), and cells that appear to be horizontal cells (N–P). Scale bar = 80 μm (A) and 40 μm (B–P). Abbreviations: GCL, ganglion cell layer; INL, inner nuclear layer; IPL, inner plexiform layer; ONL, outer nuclear layer; OPL, outer plexiform layer.