Table 6. rAAV2 serum NAb titers pre- and post-injection for first and second injected eyes.
Dog | Eye injected | Titer pre-injection | Titer 4 weeks post-injection |
---|---|---|---|
1 | First (a) | 1 in 2 | 1 in 300 |
Second (b) | 1 in 150 | 1 in 125 | |
2 | First (a) | 1 in 2 | 1 in 100 |
Second (b) | 1 in 150 | 1 in 8500 | |
3 | First (a) | 1 in 2 | 1 in 2000 |
Second (b) | 1 in 800 | 1 in 800 | |
4 | First (a) | 1 in 2 | 1 in 32 000 |
Second (b) | 1 in 8500 | 1 in 35 000 | |
5 | First (a) | 1 in 150 | 1 in 5000 |
Second (b) | 1 in 2000 | 1 in 8000 | |
6 | First (a) | 1 in 3 | 1 in 3000 |
Second (b) | 1 in 1000 | 1 in 5000 | |
7 | First (a) | 1 in 2 | 1 in 200 |
Second (b) | 1 in 25 | 1 in 25 000 | |
8 | First (a) | 1 in 2 | 1 in 3500 |
Second (b) | 1 in 200 | 1 in 3500 | |
9 | First (a) | 1 in 2 | 1 in 750 |
Second (b) | 1 in 1000 | 1 in 7500 |
Abbreviation: NAb, neutralizing antibody.