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Responses to IL-33 gene delivery in ST2-deficient animals. The top two panels show BAL cell counts in flmIL-33- and mmIL-33-expressing mice on day 14 after construct instillation in wild-type (left) and ST2 −/− (right) mice. Significant differences from AdV-NULL-challenged mice are indicated with asterisks (p < 0.05). Below, histological changes in the lungs following flmIL-33 or mmIL-33 gene delivery (H&E staining).
