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. 2011 Feb 9;31(6):2313–2320. doi: 10.1523/JNEUROSCI.4717-10.2011

Figure 2.

Figure 2.

Effect of systemic administration of mito-ABAD peptide on mitochondrial function and spatial memory. A, B, Effect on mitochondrial function. The respiratory control rate (RCR) (A), and enzyme activities associated with complexes III and IV (B) were determined in the brain mitochondria isolated from the indicated Tg mice. C, Quantification of the area occupied by HNE-4 staining in hippocampus of the indicated Tg mice. n = 3–8 mice per group. D, Spatial learning and memory were tested using a radial arm water maze in Tg mAPP mice treated with vehicle, mito-ABAD-DP (DP), or mito-ABAD-RP (RP), and non-Tg mice or Tg mAPP mice treated with vehicle (n = 7–11 mice per group). A1–A4 denote the acquisition trials, and R denotes the retention trial. *p < 0.01 compared with vehicle- or mito-ABAD-RP-treated Tg mAPP mice. #p < 0.05 compared with vehicle-treated non-Tg mice.