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. 2011 Feb 9;31(6):2313–2320. doi: 10.1523/JNEUROSCI.4717-10.2011

Figure 5.

Figure 5.

Effect of ABAD antagonizing peptide on accumulation of mitochondrial Aβ in Tg mAPP mice. A, B, ELISA for measurement of mitochondrial Aβ40 (A) and -42 (B) levels in Tg mAPP mice treated with Mito-ABAD-DP or -RP at age of 10–11 months. *p < 0.01 vs vehicle- or Mito-ABAD-RP-treated Tg mAPP mice. C, D, ELISA for Aβ40 (C) and Aβ42 (D) in the cortical mitochondria from the indicated Tg mice at 10–11 months old. *p < 0.01 vs Tg mAPP mice. E, PreP activity for degradation of biotin-Aβ. F, Quantification of density of all Aβ-immunoreactive bands incubated with mitochondrial fractions from non-Tg littermates (lanes 4–7), Tg mAPP mice (lanes 8–11), double Tg mAPP/mito-ABAD (lanes 12–15), and Tg mAPP/mito-ABAD plus anti-PreP antibody mice (lanes 16–19) using NIH ImageJ software. *p < 0.01 vs other groups of mice. n = 5–10 mice per group.