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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Am J Transplant. 2012 Mar 15;12(7):1708–1719. doi: 10.1111/j.1600-6143.2012.04009.x

Figure 2. The kinetics of DSA production in sensitized versus non-sensitized heart allograft recipients.

Figure 2

Heterotopic BALB/c heart transplants were placed into non-sensitized B6 mice or into sensitized B6 recipients four weeks after immunization with BALB/c alloantigens. Serum was collected on days 7, 14 and 21 and at six weeks post transplant, and the titers of BALB/c- and third party-reactive alloAb were determined by cell binding assay. The titers of third party-reactive alloAb in all serum samples were < 45 for IgG2c and IgG2b and < 135 for IgG1 and IgG3. The results were compared using non-parametric Mann-Whitney test. N = 4–5 mice per group at each time point.