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PreP activity/expression in Tg AD mice at age of twelve months. The cortical mitochondrial PreP from twelve-months-old Tg mice degraded biotin Aβ40/42 (A,B) and pF1β (C) Densitometry of combined immunoreactive bands (Aβ or pF1β) from the indicated Tg mice. D) Immunoblotting of mitochondrial fractions from the indicated Tg mice for PreP or Hsp60. n = 4–5 mice per group. All experiments were performed in triplicates.
