Table 2.

Comparison of Intentional and Unintentional Acetaminophen Overdose

Feature	Intentional (n = 122)	Unintentional (n = 131)	P Value
Age (years)*	34 (17–68)	38 (18–76)	NS
Female Sex	74%	73%	NS
Total Dose (grams)*	25 (1.2–90)	20 (2.5–180)	NS
Dose per day (grams)*	25 (1.2–90)	7.5 (1.0–7.8)	NS
Coma Score ≥ 3	39%	55%
Maximum ALT (U/L)*	5326 (179–19,826)	3319 (176–18,079)	NS
History of depression	45%	24%
Antidepressant use	38%	37%	NS
Narcotic compound	18%	63%
Multiple preparations	5%	38%
Spontaneous survival	66%	64%	NS
Transplantation	7%	9%	NS
Death without transplantation	27%	27%	NS

Summarized from reference 50 on a prospective consecutive series of 275 cases of ALF due to acetaminophen overdose, in 22 of whom the intent could not be determined.

^*Median values (range).