Table 1.

Associations between genetic ancestry and autoantibodies with age, sex, and interferon-α (IFN-α) as covariates.

		IFN-α			Anti-RNP
	β	SE	p	β	SE	p
Sex	−0.6465	0.431	0.1336	−0.0362	0.4689	0.9385
Age	−0.0408	0.0111	0.0002	−0.0162	0.0122	0.1848
IFN-α*	NA	NA	NA	1.4942	0.3303	6.1 × 10−6
PC1	−1.4764	0.4889	0.0025	−2.1128	0.5576	0.0002
PC2**	−3.6297	2.3468	0.1219	—	—	—
PC3**	—	—	—	—	—	—
		Anti-RO			Anti-SM
	β	SE	p	β	SE	p
Sex	−0.1825	0.4459	0.6823	0.0313	0.5299	0.9529
Age	0.0072	0.5235	0.5235	−0.0263	0.0132	0.0466
IFN-α	0.7732	0.3179	0.0150	0.7354	0.3605	0.0413
PC1	−1.2298	0.5261	0.0194	−1.6780	0.6612	0.0112
PC2**	—	—	—	−4.3808	2.4314	0.0716
PC3**	1.9206	1.7241	0.2653	—	—	—
		Anti-La			Anti-dsDNA
	β	SE	p	β	SE	p
Sex	0.1040	0.686	0.8795	0.2188	0.4638	0.6372
Age	0.0129	0.0155	0.4038	−0.0273	0.012	0.023
IFN-α	1.0511	0.494	0.0334	0.8224	0.3168	0.0094
PC1**	−1.5001	0.8949	0.0937	—	—	—
PC2**	−6.1517	2.991	0.0397	—	—	—
PC3**	—	—	—	—	—	—

^*IFN-α was the dependent variable, so it was not used as a covariate.

^**Values were omitted if components did not meet the first-pass criterion (p < 0.20), indicated with a dash. PC: principal component; NA: not applicable.