Figure 1. Assessment of GdBCA induced NFκB dependent activation in HEK293 cells expressing a single TLR or NLR.
Measurement of NFκB dependent secreted alkaline phosphatase (SEAP) levels in HEK293 cells expressing a single TLR or NLR following exposure to 5 mM Omniscan®, gadodiamide or ProHance®. Values represent the mean (+/− SD) absorbance at 650 nm of 2 replicates of 2 separate experiments on HEK293 cells in culture. Statistical significance was calculated by comparing each Gd compound to the saline control. *: p<0.05; **: p < 0.01; ***: p<0.001.