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Release of cytochrome C by PALA treatment: (A) 041 and its derivatives 041-p53 and 041-ddp73; (B) PC3 and pC3-p53; and (C) A549-shGFP and A549-shp53 cells were treated with 250 µM/L of PALA for 72 h and expression of cytochrome c and Cox4 in the cytosolic and mitochondrial fractions were examined after cytoplasmic and mitochondrial fractionation. Representative results from three independent experiments are shown.
