Table 2.

The associations of demographic variables and serum AFP value with the risk of developing HCC in HBV patients.

Variables	Number (%) of patients (N=617)	Person-years of follow-up	Number (%) of HCC cases (N=61)	Incidence rate per 100,000 person-years	HR (95% CI) *	P value
Age (Year)
≤39	233(40.88)	1651	8	485	Reference
40–49	194(34.04)	1179	17	1442	1.45 (0.71–2.96)	0.30
50–59	108(18.95)	531	26	4896	6.28 (3.12–12.63)	<0.0001
≥60	35(6.14)	148	3	2027	2.11 (0.85–11.40)	0.09
Sex
Female	200(32.41)	1160	9	776	Reference
Male	417(67.59)	2625	52	1981	1.90 (0.84–4.30)	0.12
Smoking status
Never	412(66.77)	2544	29	1140	Reference
Ever	205(33.23)	1241	32	2579	1.65 (0.81–3.34)	0.17
Drinking status
No	376(60.94)	2369	30	1266	Reference
Yes	241(39.06)	1416	31	2189	1.10 (0.56–2.16)	0.78
Cirrhosis
No	390(63.21)	2315	7	302	Reference
Yes	227(36.79)	1470	54	3673	8.02 (3.38–19.05)	<0.0001
Family history of HBV
No	305(49.31)	1894	31	1637	Reference
Yes	312(50.57)	1891	30	1586	0.94 (0.52–1.69)	0.83
Family history of cirrhosis
No	501(81.20)	3106	45	1449	Reference
Yes	116(18.80)	679	16	2356	3.20 (1.08–9.43)	0.04
Family history of cancer
No	407(65.96)	2547	37	1453	Reference
Yes	210(34.04)	1238	24	1939	1.13 (0.65–1.99)	0.67
AFP
≤median	300(48.62)	1872	15	801	Reference
>median	317(51.38)	1913	46	2405	2.73 (1.25–5.99)	0.01

^*Adjusted for age, sex, smoking status, drinking status, cirrhosis, family history of HBV, family history of cirrhosis, family history of cancer, and AFP, where appropriate.