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Cartilage degradation induced by IL-1α stimulation. A, Proteoglycan release in cultured cartilage explants from wild-type (WT) and Col2-Ugcg−/− littermates (n = 5 per group). Data shown are mean ± SEM. * = P < 0.01, ** = P < 0.05. B, Histological findings of cartilage explants cultured with IL-1α from WT and Col2-Ugcg−/− littermates (from top to bottom, TB, toluidine blue; Saf-O, safranin O; MMP-13 immunostaining, and TUNEL staining). Scale bars = 100 µm.
