Table 4.
| a: Logistic Regression for New Experimentation (N=1118) | ||||||
|---|---|---|---|---|---|---|
| Psychosocial factors only |
Psychosocial and genetic factors |
|||||
| OR | 95% CI | p-value | OR | 95% CI | p-value | |
| Social and psychological factors | ||||||
| Cognitively susceptible | 2.34 | 1.62 – 3.37 | < 0.001 | 2.55 | 1.74 – 3.73 | < 0.001 |
| Age 13 at baseline | 2.13 | 1.51 – 2.99 | < 0.001 | 2.27 | 1.59 – 3.23 | < 0.001 |
| Male | 1.87 | 1.35 – 2.59 | < 0.001 | 1.96 | 1.40 – 2.75 | < 0.001 |
| Outcome expectations | 1.69 | 1.11 – 2.57 | 0.014 | 1.65 | 1.07 – 2.53 | 0.023 |
| Household member smokes | 1.51 | 1.22 – 1.86 | < 0.001 | 1.53 | 1.23 – 1.90 | < 0.001 |
| Risk taking tendencies | 1.35 | 1.12 – 1.64 | 0.002 | 1.30 | 1.07 – 1.59 | 0.009 |
| Gene (SNP) | ||||||
| SNAP25 (rs8119844) | – | – | – | 0.26 | 0.11 – 0.61 | 0.002 |
| OPRM1 (rs9322451) | – | – | – | 0.53 | 0.35 – 0.81 | 0.003 |
| HTR1B (rs6297) | – | – | – | 1.89 | 1.17 – 3.03 | 0.009 |
| SLC6A3 (rs10052016) | – | – | – | 0.64 | 0.45 – 0.90 | 0.009 |
| HTR2A (rs9567732) | – | – | – | 0.70 | 0.50 – 0.98 | 0.038 |
| DRD2 (rs12422191) | – | – | – | 2.10 | 1.31 – 3.36 | 0.002 |
| AIC Criteria | 958.41 | 930.10 | ||||
| b: Logistic Regression for New Experimentation Stratified by Cognitive Susceptibility | ||||||
|---|---|---|---|---|---|---|
| Committed Never Smoker (N = 872) |
Susceptible (N = 246) |
|||||
| OR | 95% CI | p-value | OR | 95% CI | p-value | |
| Social and psychological factors | ||||||
| Age 13 at baseline | 2.04 | 1.31 – 3.20 | 0.002 | 3.00 | 1.61 – 5.62 | 0.001 |
| Male | 2.08 | 1.37 – 3.17 | 0.001 | 1.64 | 0.89 – 3.02 | 0.116 |
| Outcome expectations | 2.87 | 1.63 – 5.06 | < 0.001 | 0.93 | 0.48 – 1.80 | 0.825 |
| Household member smokes | 1.52 | 1.15 – 2.01 | 0.003 | 1.63 | 1.12 – 2.38 | 0.011 |
| Risk taking tendencies | 1.46 | 1.14 – 1.88 | 0.003 | 1.17 | 0.83 – 1.64 | 0.379 |
| Gene (SNP) | ||||||
| SNAP25 (rs8119844) | 0.21 | 0.08 – 0.53 | 0.001 | 0.42 | 0.04 – 4.10 | 0.454 |
| OPRM1 (rs9322451) | 0.54 | 0.32 – 0.92 | 0.025 | 0.54 | 0.26 – 1.11 | 0.095 |
| HTR1B (rs6297) | 2.10 | 1.20 – 3.66 | 0.009 | 1.44 | 0.58 – 3.58 | 0.433 |
| SLC6A3 (rs10052016) | 0.85 | 0.56 – 1.28 | 0.429 | 0.37 | 0.20 – 0.68 | 0.002 |
| HTR2A (rs9567732) | 0.80 | 0.53 – 1.21 | 0.287 | 0.46 | 0.25 – 0.86 | 0.015 |
| DRD2 (rs12422191) | 1.49 | 0.81 – 2.74 | 0.199 | 4.88 | 1.89 – 12.56 | 0.001 |
| AIC Criteria | 640.95 | 291.66 | ||||
•
New experimentation includes participants who reported that they had not experimented at baseline and reported that they had experimented on one or more of the four subsequent contacts.