A) Postoperative brain water content. Sham intraperitoneal (IP) (n=6), vehicle IP (n=6), dexmedetomidine (DEX) 10 (n=8), DEX 30 (n=6), sham IV (n=7), vehicle IV (n=4), DEX 10/5 (n=8), DEX 30/15 (n=6). *P<0.001 when compared with respective sham group. B–D) Physiologic monitoring results (n=4 per study group) for B) blood glucose, C) mean arterial blood pressure (MAP), and D) heart rate (HR). *1P<0.001, #1P<0.01, and #P<0.05 after one-way ANOVA testing of the treatment groups in the labeled time period. Tukey’s pairwise multiple comparison procedure (results not displayed) showed at least a P<0.05 when comparing MAP of DEX 10 and DEX 30 with naïve and vehicle at 10–50 min, and with naïve at 60 min. P<0.05 comparing HR of DEX 10 with naïve and vehicle at 20 and 30 min, and with DEX 10 compared with naïve and vehicle at 50 min. P<0.05 comparing blood glucose of DEX 10 with naïve and vehicle at 30 min, and DEX 30 with naïve at 30 min. Values shown as mean + SD.