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. Author manuscript; available in PMC: 2013 Apr 27.
Published in final edited form as: Circ Res. 2012 Mar 27;110(9):1202–1210. doi: 10.1161/CIRCRESAHA.111.256370

Figure 6. Inhibition of platelet GPIbα or its interaction with leukocyte Mac-1 ameliorates EAE in mice.

Figure 6

(A, B) EAE was induced in female WT mice. Mice were treated i.p. with Fab to GPIbα or control Fab (each 75µg/mouse) (A) on days 12, 14 and 16 or (B) on days 15, 17 and 19 (indicated by the arrows). Clinical disease scores are shown. Data are mean +/− SEM (n=11–12 mice per group in A; n=7 mice per group in B). * indicates p<0.05 as compared to control Fab group on the same day. (C) Similarly, mice were treated i.v. with anti-M2 antibody blocking specifically the Mac-1/GPIbα interaction or control rabbit antibody on days 12, 14 and 16 (each at 47 µg/mouse), as indicated by the arrows. Clinical scores are shown. Data are mean +/− SEM (n=7 mice per group). * indicates p<0.05 as compared to control antibody group on the same day.